Abstract | BACKGROUND: Neutrophils are increased in the airways and in induced sputum of severe asthma patients. We determined the expression of activation markers from circulating neutrophils in severe asthma, and their supressibility by corticosteroids. METHODS: We compared blood neutrophils from mild, moderate-to-severe and severe steroid-dependent asthma, and non-asthmatics (n = 10 each). We examined the effect of adding or increasing oral prednisolone (30 mg/day;1 week). RESULTS: CONCLUSION: Because blood neutrophils in severe asthma are activated and are not inhibited by oral corticosteroids, they may be important in the pathogenesis of severe asthma.
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Authors | Bhupinder S Mann, Kian Fan Chung |
Journal | Respiratory research
(Respir Res)
Vol. 7
Pg. 59
(Apr 06 2006)
ISSN: 1465-993X [Electronic] England |
PMID | 16600024
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Asthma
(drug therapy, immunology)
- Biomarkers
(blood)
- Cells, Cultured
- Female
- Humans
- Male
- Middle Aged
- Neutrophil Activation
(drug effects, immunology)
- Neutrophils
(drug effects, immunology)
- Prednisolone
(pharmacology, therapeutic use)
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