Abstract | BACKGROUND: METHODS: This study was carried out at the Department of Obstetrics and Gynaecology, Islamic International Medical Complex (IIMC) Islamabad, from October 2001 to March 2003. Fifty women fulfilling the clinical and biochemical criteria for PCOS and hyperinsulinemia were enrolled. Metformin was started at an oral dose of 500mg/day and maintained at 1500mg for 6 months. Besides ultrasonography and body weight. serum FSH, LH, fasting insulin, fasting blood sugar and creatinine levels were performed. After six months menstrual cyclicity, fasting insulin levels, day 21 serum progesterone and body weights were assessed. RESULTS: After six months of Metformin therapy, menstrual regularity was achieved in 19 out of 22 women (86%). Out of these 11 women (50%) were ovulating at six months. On Metformin, the median fasting serum insulin decreased from 23.6 micro U/ml to 20.2 micro U/ml (P<0.05). There was no significant weight reduction (p=0.096) with Metformin in six months. Data was analyzed using SPSS by paired t-test.
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Authors | Shamsa Zafar |
Journal | Journal of Ayub Medical College, Abbottabad : JAMC
(J Ayub Med Coll Abbottabad)
2005 Oct-Dec
Vol. 17
Issue 4
Pg. 54-6
ISSN: 1025-9589 [Print] Pakistan |
PMID | 16599037
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Hypoglycemic Agents
- Insulin
- Metformin
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Topics |
- Adolescent
- Adult
- Anovulation
(drug therapy, etiology)
- Female
- Humans
- Hyperinsulinism
(drug therapy)
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(blood)
- Menstruation Disturbances
(drug therapy)
- Metformin
(therapeutic use)
- Polycystic Ovary Syndrome
(physiopathology)
- Prospective Studies
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