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[LMP-420, a new therapeutic approach for cerebral malaria?].

AuthorsSamuel C Wassmer, George J Cianciolo, Valéry Combes, Georges E Grau
JournalMedecine sciences : M/S (Med Sci (Paris)) Vol. 22 Issue 4 Pg. 343-5 (Apr 2006) ISSN: 0767-0974 [Print] France
Vernacular TitleLMP-420, un nouvelle approche thérapeutique pour le paludisme cérébral?
PMID16597395 (Publication Type: News)
Chemical References
  • 2-amino-6-chloro-9-((5-dihydroxyboryl)pentyl)purine
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antimalarials
  • Boron Compounds
  • CCL2 protein, human
  • Chemokine CCL2
  • I-kappa B Proteins
  • NF-kappa B
  • Purines
  • Receptors, Cell Surface
  • Tumor Necrosis Factor-alpha
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
  • Antimalarials (pharmacology, therapeutic use)
  • Boron Compounds (pharmacology, therapeutic use)
  • Cell Adhesion (drug effects)
  • Cells, Cultured (drug effects, metabolism)
  • Chemokine CCL2 (antagonists & inhibitors, metabolism)
  • Child, Preschool
  • Depression, Chemical
  • Drug Evaluation, Preclinical
  • Endothelial Cells (drug effects, metabolism)
  • Female
  • Gene Expression Regulation (drug effects)
  • Humans
  • I-kappa B Proteins (metabolism)
  • Infant
  • Infant, Newborn
  • Intercellular Adhesion Molecule-1 (biosynthesis, genetics)
  • Malaria, Cerebral (drug therapy)
  • Malaria, Falciparum (drug therapy)
  • Male
  • NF-kappa B (metabolism)
  • Phosphorylation (drug effects)
  • Plasmodium falciparum (physiology)
  • Pregnancy
  • Pregnancy Complications, Infectious (drug therapy)
  • Protein Processing, Post-Translational (drug effects)
  • Purines (pharmacology, therapeutic use)
  • Receptors, Cell Surface (drug effects)
  • Th1 Cells (metabolism)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)
  • Vascular Cell Adhesion Molecule-1 (biosynthesis, genetics)

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