Abstract | AIM: METHODS: A multicenter, open-labeled, controlled, randomized, three-arm comparative study on 90 women aged 18 years or over with clinically and microbiologically proven BV. RESULTS: The lactobacilli colony count significantly increased over time in all three arms. At day 14, growth of lactobacilli was significantly higher among patients in the lactic acid gel and combination treatment arms. Significant reduction of malodorous vaginal discharge (whiff test) and lowest recurrence of BV were noted in the metronidazole plus lactic acid gel arm. Regarding disappearance of signs of BV, there was significant decrease in the pH level and frequency of clue cell positive patients across time but was not significantly different across treatment groups. Only one patient (3%, 1/60) among those who received lactic acid gel complained of increased curd-like discharge. Six patients (10%, 6/60) who received metronidazole complained of epigastric pain/discomfort, dizziness and dyspnea. CONCLUSIONS:
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Authors | Ditas Cristina D Decena, Jennifer T Co, Ricardo M Manalastas Jr, Evelyn P Palaypayon, Christia S Padolina, Judith M Sison, Louella A Dancel, Marievi A Lelis |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 32
Issue 2
Pg. 243-51
(Apr 2006)
ISSN: 1341-8076 [Print] Australia |
PMID | 16594932
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Drug Combinations
- Immune Sera
- Soaps
- Vaginal Creams, Foams, and Jellies
- Metronidazole
- Lactic Acid
- lactacyd
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Topics |
- Adult
- Anti-Infective Agents
(administration & dosage)
- Drug Combinations
- Female
- Humans
- Hydrogen-Ion Concentration
- Immune Sera
(administration & dosage, adverse effects)
- Lactic Acid
(administration & dosage, adverse effects)
- Lactobacillus
(growth & development)
- Metronidazole
(administration & dosage, adverse effects)
- Odorants
- Philippines
- Recurrence
- Soaps
- Vagina
(chemistry, microbiology)
- Vaginal Creams, Foams, and Jellies
(administration & dosage)
- Vaginal Discharge
- Vaginosis, Bacterial
(drug therapy)
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