Drug testing for activity against varicella-zoster virus in hairless guinea pigs.

Abstract

Inoculation of congenitally hairless guinea pigs with varicella-zoster virus (VZV) (Oka strain) results in a self-limited exanthematous infection analogous to varicella in children. Administration of acyclovir or 6-methoxypurine arabinoside modified the course of infection. This model should facilitate pre-clinical testing of putative anti-VZV agents.

• Authors: M G Myers, L R Stanberry
• Journal: Antiviral research (Antiviral Res) Vol. 15 Issue 4 Pg. 341-4 (May 1991) ISSN: 0166-3542 [Print] Netherlands
• PMID: 1659314 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Acyclovir

Topics

• Acyclovir (pharmacology)
• Animals
• Antiviral Agents (pharmacology)
• Cells, Cultured
• Child, Preschool
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Exanthema (complications, drug therapy)
• Guinea Pigs
• Herpes Zoster (complications, drug therapy)
• Herpesvirus 3, Human (drug effects)
• Humans