Abstract |
The radiosensitizing effect of the nitroimidazole derivative RK28 and diethyldithiocarbamate (DDC), which is an inhibitor of superoxide dismutase activity, was examined in vitro by using Meth A tumor cells. The radiosensitizing effect of 0.5 mM RK28 was observed in both of 10 Gy and 15 Gy irradiated groups. The addition of 5 x 10(-7) M DDC also enhanced the radiation-induced proliferation inhibition. Marked enhancement of the antiproliferative effect was observed in combined use of 0.2 mM or 0.5 mM RK28 with 2 x 10(-7) M or 5 x 10(-7) M DDC. These results suggest that enhanced oxygen effect could be expected through combined use of the ionizing irradiation with both of these agents.
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Authors | H Mashiba, K Matsunaga, K Hata |
Journal | Life sciences
(Life Sci)
Vol. 49
Issue 19
Pg. 1419-25
( 1991)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 1658511
(Publication Type: Journal Article)
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Chemical References |
- Cobalt Radioisotopes
- Radiation-Sensitizing Agents
- 1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole
- Misonidazole
- Ditiocarb
- Superoxide Dismutase
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Topics |
- Animals
- Cell Division
(drug effects, radiation effects)
- Cobalt Radioisotopes
- Ditiocarb
(pharmacology)
- Drug Synergism
- Mice
- Mice, Inbred BALB C
- Misonidazole
(analogs & derivatives, pharmacology)
- Radiation-Sensitizing Agents
(pharmacology)
- Superoxide Dismutase
(antagonists & inhibitors)
- Tumor Cells, Cultured
(drug effects, radiation effects)
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