[Unrelated donor peripheral blood stem cell transplantation for hematologic malignancies].

Abstract

This study was aimed to explore feasibility and efficacy of unrelated donor peripheral blood stem cell transplantation (UD-PBSCT) in treatment of hematologic malignancies. Ten patients with hematologic malignancies underwent high resolution DNA based typing HLA-matched or 1 locus mismatched UD-PBSCT. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preconditioning regimen in all cases. All patients received mycophenolate mofetile, cyclosporin A and short-term methotrexate with CD25 antibody as the graft-versus-host disease (GVHD) prophylaxis. The results showed that rapid engraftment was observed in all cases who presented full donor chimerism at 28 days post transplantation by STR-PCR. The median time of neutrophil recovery > 0.5 x 10(9)/L, platelet recovery > 20 x 10(9)/L was 13, 17.5 days respectively after transplantation. The incidence of acute GVHD was 3 cases (one case with grade I was recovered from GVHD by himself, one case with grade III was cured, one case with grade VI was died). It is concluded that above-mentioned preconditioning regimen and GVHD prophylaxis are effective approaches for unrelated donor peripheral blood stem cell transplantation in hematopoietic malignancies.

• Authors: Chun-Ji Gao, Wan-Ming DA, Bo-Long Zhang, Xiao-Ping Han, Yu Jing, Hong-Hua Li, Jian Bo, Hai-Yan Zhu, Hai-Jie Jin, Xiao-Xiong Wu, Quan-Xun Wang, Su-Sia Li, Wen-Rong Huang, Li Yu
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 14 Issue 1 Pg. 112-5 (Feb 2006) ISSN: 1009-2137 [Print] China
• PMID: 16584604 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Blood Donors
• Female
• Graft vs Host Disease (prevention & control)
• Humans
• Male
• Peripheral Blood Stem Cell Transplantation (methods)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)