Abstract |
We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor.
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Authors | S T Roodman, M D Woon, J W Hoffmann, P Theodorakis, C C Tsai, H N Wu, C C Tsai |
Journal | Journal of medical primatology
(J Med Primatol)
Vol. 20
Issue 4
Pg. 201-5
(Jun 1991)
ISSN: 0047-2565 [Print] Denmark |
PMID | 1658327
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Culture Media
- Interleukin-6
- RNA, Messenger
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Topics |
- Animals
- Cell Line
- Culture Media
- Enzyme-Linked Immunosorbent Assay
- Fibroma
(complications)
- Immunohistochemistry
- Interleukin-6
(analysis, blood, genetics)
- Macaca nemestrina
- Polymerase Chain Reaction
- RNA, Messenger
(analysis)
- Retroperitoneal Neoplasms
(complications)
- Retroviruses, Simian
(immunology)
- Simian Acquired Immunodeficiency Syndrome
(complications)
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