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Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS.

Abstract
We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor.
AuthorsS T Roodman, M D Woon, J W Hoffmann, P Theodorakis, C C Tsai, H N Wu, C C Tsai
JournalJournal of medical primatology (J Med Primatol) Vol. 20 Issue 4 Pg. 201-5 (Jun 1991) ISSN: 0047-2565 [Print] Denmark
PMID1658327 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Culture Media
  • Interleukin-6
  • RNA, Messenger
Topics
  • Animals
  • Cell Line
  • Culture Media
  • Enzyme-Linked Immunosorbent Assay
  • Fibroma (complications)
  • Immunohistochemistry
  • Interleukin-6 (analysis, blood, genetics)
  • Macaca nemestrina
  • Polymerase Chain Reaction
  • RNA, Messenger (analysis)
  • Retroperitoneal Neoplasms (complications)
  • Retroviruses, Simian (immunology)
  • Simian Acquired Immunodeficiency Syndrome (complications)

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