Abstract | BACKGROUND: METHODS: A 63-year-old male taking amlodipine for his hypertension presented with a 3-week gingival enlargement. Although the obvious clinical impression was that of drug-induced gingival enlargement, an incisional biopsy was performed to corroborate chemical enlargement while ruling out diseases such as lymphoma and leukemia. RESULTS: Microscopic examination of the thickened gingiva revealed surface stratified squamous epithelium having needle-like rete pegs characteristic of drug-induced gingival enlargement. Beneath the surface epithelium, the fibrous tissue was virtually replaced by a dense infiltrate of malignant cells. Immunohistochemical studies were performed with CD117 and myeloperoxidase identifying the malignant cell population as myeloblasts, leading to a diagnosis of myeloid sarcoma. CONCLUSION:
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Authors | Angela J Yoon, Carla Pulse, Lori D Cohen, Timothy A Lew, David J Zegarelli |
Journal | Journal of periodontology
(J Periodontol)
Vol. 77
Issue 1
Pg. 119-22
(Jan 2006)
ISSN: 0022-3492 [Print] United States |
PMID | 16579712
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antihypertensive Agents
- Amlodipine
- Proto-Oncogene Proteins c-kit
- Leukocyte Common Antigens
|
Topics |
- Amlodipine
(adverse effects)
- Antihypertensive Agents
(adverse effects)
- Biopsy
- Diagnosis, Differential
- Epithelium
(pathology)
- Gingival Neoplasms
(complications, diagnosis)
- Gingival Overgrowth
(chemically induced, diagnosis)
- Humans
- Leukemia, Myeloid
(complications, diagnosis)
- Leukocyte Common Antigens
(analysis)
- Male
- Middle Aged
- Proto-Oncogene Proteins c-kit
(analysis)
|