Aerosolized ribavirin-induced reversible hepatotoxicity in a hematopoietic stem cell transplant recipient with Hodgkin lymphoma.

Abstract

We describe a case of acute hepatic toxicity associated with aerosolized ribavirin in a bone marrow transplant recipient with documented respiratory syncytial virus infection. The temporal relationship with drug administration and the liver biopsy results suggested drug-induced hepatic injury. As the use of aerosolized ribavirin to treat respiratory syncytial virus infections continues, it is imperative that careful attention be paid to possible adverse effects of therapy in the high-risk population of immunosuppressed patients.

• Authors: Jorge Chaves, Auris Huen, Carlos Bueso-Ramos, Amar Safdar, Saroj Vadhan-Raj
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 42 Issue 8 Pg. e72-5 (Apr 15 2006) ISSN: 1537-6591 [Electronic] United States
• PMID: 16575720 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Aerosols
• Antiviral Agents
• Ribavirin
• Bilirubin

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aerosols
• Antiviral Agents (administration & dosage, therapeutic use)
• Bilirubin (blood)
• Bone Marrow Transplantation (adverse effects)
• Female
• Graft vs Host Disease
• Hodgkin Disease (drug therapy)
• Humans
• Liver (drug effects, pathology)
• Liver Function Tests
• Ribavirin (administration & dosage, adverse effects, therapeutic use)
• Stem Cell Transplantation (adverse effects)