HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas.

AbstractPURPOSE:
The aim of this study was to investigate the immunohistochemical expression of p16, p53, and p63 proteins according to some pathologic parameters related to colorectal adenomas and adenocarcinomas such as grade of dysplasia and histologic type.
METHODS:
Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubular-villous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30). The p63-positive cases were submitted to double immunolabeling with the cytokeratin 5 (CK5).
RESULTS:
The p16 and p53 labelings were observed in some adenomas and adenocarcinomas but without any association with p63 expression, histologic type, or grade of differentiation of the neoplasm. P63 expression was found mainly in the villous adenomas and in the poorly differentiated adenocarcinomas. The poorly differentiated adenocarcinomas also exhibited coexpression of CK5 and p63.
CONCLUSIONS:
Despite both p16 and p53 having been detected in colorectal neoplasms, they were not related to the different histologic variables nor to the expression of p63. However, p63 expression was closely associated with villous adenomas and poorly differentiated adenocarcinomas. Thus, p63 may represent a marker of poor differentiation in colorectal neoplasms. The coexpression of p63 and CK5 observed in this study could be related to divergent differentiation during the development of colorectal cancer, although further studies are warranted to refine the understanding of this process.
AuthorsFabiana Pirani Carneiro, Leandra Náira Zambelli Ramalho, Sérgio Britto-Garcia, Alfredo Ribeiro-Silva, Sérgio Zucoloto
JournalDiseases of the colon and rectum (Dis Colon Rectum) Vol. 49 Issue 5 Pg. 588-94 (May 2006) ISSN: 0012-3706 [Print] United States
PMID16575619 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Phosphoproteins
  • TP63 protein, human
  • Trans-Activators
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Keratins
Topics
  • Adenocarcinoma
  • Adenoma
  • Biomarkers, Tumor (genetics, metabolism)
  • Colorectal Neoplasms (genetics, metabolism, pathology)
  • DNA-Binding Proteins
  • Genes, Tumor Suppressor
  • Genes, p16
  • Genes, p53
  • Humans
  • Immunohistochemistry
  • Keratins (metabolism)
  • Phosphoproteins (metabolism)
  • Trans-Activators (metabolism)
  • Transcription Factors
  • Tumor Suppressor Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: