Abstract | PURPOSE: The aim of this study was to investigate the immunohistochemical expression of p16, p53, and p63 proteins according to some pathologic parameters related to colorectal adenomas and adenocarcinomas such as grade of dysplasia and histologic type. METHODS: RESULTS: CONCLUSIONS: Despite both p16 and p53 having been detected in colorectal neoplasms, they were not related to the different histologic variables nor to the expression of p63. However, p63 expression was closely associated with villous adenomas and poorly differentiated adenocarcinomas. Thus, p63 may represent a marker of poor differentiation in colorectal neoplasms. The coexpression of p63 and CK5 observed in this study could be related to divergent differentiation during the development of colorectal cancer, although further studies are warranted to refine the understanding of this process.
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Authors | Fabiana Pirani Carneiro, Leandra Náira Zambelli Ramalho, Sérgio Britto-Garcia, Alfredo Ribeiro-Silva, Sérgio Zucoloto |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 49
Issue 5
Pg. 588-94
(May 2006)
ISSN: 0012-3706 [Print] United States |
PMID | 16575619
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- DNA-Binding Proteins
- Phosphoproteins
- TP63 protein, human
- Trans-Activators
- Transcription Factors
- Tumor Suppressor Proteins
- Keratins
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Topics |
- Adenocarcinoma
- Adenoma
- Biomarkers, Tumor
(genetics, metabolism)
- Colorectal Neoplasms
(genetics, metabolism, pathology)
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Genes, p16
- Genes, p53
- Humans
- Immunohistochemistry
- Keratins
(metabolism)
- Phosphoproteins
(metabolism)
- Trans-Activators
(metabolism)
- Transcription Factors
- Tumor Suppressor Proteins
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