Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSIONS: These results suggest that G-CSF acts directly on the myocardium during ischemia-reperfusion injury and has acute nongenomic cardioprotective effects through the Akt-endothelial NOS pathway.
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Authors | Kazutaka Ueda, Hiroyuki Takano, Hiroshi Hasegawa, Yuriko Niitsuma, Yingjie Qin, Masashi Ohtsuka, Issei Komuro |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 26
Issue 6
Pg. e108-13
(Jun 2006)
ISSN: 1524-4636 [Electronic] United States |
PMID | 16574892
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardiotonic Agents
- Granulocyte Colony-Stimulating Factor
- Nitric Oxide Synthase Type III
- Proto-Oncogene Proteins c-akt
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Topics |
- Animals
- Cardiotonic Agents
(pharmacology)
- Enzyme Activation
- Granulocyte Colony-Stimulating Factor
(pharmacology)
- In Vitro Techniques
- Male
- Myocardial Infarction
(pathology)
- Myocardial Reperfusion Injury
(prevention & control)
- Myocardium
(metabolism)
- Nitric Oxide Synthase Type III
(metabolism)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Rats
- Rats, Wistar
- Signal Transduction
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