| Abstract | We have previously shown that ML-7, which inhibits myosin light chain kinase (MLCK), induces apoptosis in transformed and non-transformed cells. We have extended these studies and found that ML-7 stimulates the ability of etoposide to induce apoptosis in Mm5MT mouse mammary adenocarcinoma cells and Mat-Ly-Lu rat prostate cancer cells in vitro. ML-7 was also found to have a chemopreventive effect using an in vitro mouse mammary organ culture model. In vivo experiments demonstrated that ML-7 retards the growth of mammary tumours in mice and prostate tumours in rats. Moreover, ML-7 significantly stimulates the ability of etoposide to prevent the growth of established mammary tumours in mice and prostate tumours in rats. These results provide evidence for the efficacy of ML-7 as an adjuvant to etoposide in these models and warrants further development. |
| Authors | Lian-Zhi Gu, Wen-Yang Hu, Nenad Antic, Rajendra Mehta, Jerrold R Turner, Primal de Lanerolle
(Affiliation: Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612-7342, USA.)
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| Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 42
Issue 7
Pg. 948-57
(May 2006)
ISSN: 0959-8049 England |
| PMID | 16574402
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Azepines
- Naphthalenes
- ML 7
- Etoposide
- Myosin-Light-Chain Kinase
|
| Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Animals
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Apoptosis
(drug effects)
- Azepines
(pharmacology)
- Cell Division
- Chemotherapy, Adjuvant
- Etoposide
(therapeutic use)
- Humans
- Male
- Mammary Neoplasms, Experimental
(drug therapy, pathology)
- Mice
- Mice, Inbred BALB C
- Myosin-Light-Chain Kinase
(antagonists & inhibitors)
- Naphthalenes
(pharmacology)
- Prostatic Neoplasms
(drug therapy, pathology)
- Random Allocation
- Rats
|
