The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis.

Abstract

Since lignans have been suggested to have some cancer-protective effects, flaxseed, the most abundant source of lignan precursors, was tested for its effect on early markers of risk for mammary carcinogenesis. Supplementation of a high-fat diet with flaxseed flour (FF) or defatted flaxseed meal (FM) (5% or 10%) reduced the epithelial cell proliferation by 38.8-55.4% and nuclear aberrations by 58.8-65.9% in female rat mammary gland, with optimum effects seen with the 5% FF. These protective effects were accompanied by increases in urinary lignan excretion indicating that they may be related to the ability of flaxseed to provide lignan precursors.

• Authors: M Serraino, L U Thompson
• Journal: Cancer letters (Cancer Lett) Vol. 60 Issue 2 Pg. 135-42 (Nov 1991) ISSN: 0304-3835 [Print] Ireland
• PMID: 1657368 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Biomarkers, Tumor
• Lignans
• Lignin

Topics

• Animals
• Antineoplastic Agents, Phytogenic
• Biomarkers, Tumor
• Cell Division (drug effects)
• Dose-Response Relationship, Drug
• Epithelium (pathology)
• Female
• Lignans
• Lignin (pharmacology)
• Mammary Neoplasms, Animal (diet therapy, prevention & control)
• Mutation (drug effects)
• Rats
• Rats, Inbred Strains
• Regression Analysis
• Weight Gain (drug effects)