[Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil].

Abstract

OBJECTIVE:

To explore the effect of intralesional injection of low concentration 5-fluorouracil (5-FU) on inhibition of angiogenesis of keloid.

METHODS:

35 patients with 51 keloids were treated with intralesional injection of 5-FU (2-5 mg/ml) biweekly. After 3-6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months.

RESULTS:

The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77%. For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14%. Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission.

CONCLUSION:

Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.

• Authors: Xiao-li Wu, Wei Liu, Yi-lin Cao
• Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery (Zhonghua Zheng Xing Wai Ke Za Zhi) Vol. 22 Issue 1 Pg. 44-6 (Jan 2006) ISSN: 1009-4598 [Print] China
• PMID: 16573165 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Fluorouracil

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Combined Modality Therapy
• Female
• Fluorouracil (administration & dosage, therapeutic use)
• Humans
• Hyperplasia
• Keloid (drug therapy, pathology)
• Male
• Treatment Outcome