Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds.

Abstract

OBJECTIVE:

To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.

METHODS:

Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (CII)-reactive antibodies and the pathological scores of CIA were assessed.

RESULTS:

Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 +/- 3.35 days vs 16.56 +/- 4.75 days, P < 0.05) and higher level of CII-reactive antibodies (0.2274 +/- 0.1390 microg/ml vs 0.1101 +/- 0.0560 microg/ml, P < 0.05) were observed, but the pathological scores of CIA remained unchanged. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 +/- 3.43 scores vs 11.11 +/- 5.64 scores) and bone erosion (0.22 +/- 0.44 scores vs 1.67 +/- 1.50 scores) of CIA on NTG mice (P < 0.05), NTG YQXQFS group compared with NTG experimental group.

CONCLUSION:

YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.

• Authors: Fen Li, Hong Wu, Jun-wei Deng, Song-qing Fan, Jing Tian, Jie-sheng Gao, Ya-hui Zhu, Guang-xiu Lu
• Journal: Chinese journal of integrative medicine (Chin J Integr Med) Vol. 12 Issue 1 Pg. 46-9 (Mar 2006) ISSN: 1672-0415 [Print] China
• PMID: 16571284 (Publication Type: Journal Article)

Chemical References

• Antibodies
• Antirheumatic Agents
• Collagen Type II
• Drugs, Chinese Herbal
• HLA-DR4 Antigen
• yangqixue qufengshi recipe

Topics

• Animals
• Antibodies (blood)
• Antirheumatic Agents (therapeutic use)
• Arthritis, Experimental (drug therapy)
• Arthritis, Rheumatoid (drug therapy, immunology, pathology)
• Collagen Type II (immunology)
• Drugs, Chinese Herbal (therapeutic use)
• HLA-DR4 Antigen (genetics)
• Mice
• Mice, Inbred Strains
• Mice, Knockout