[Expression of perlecan in laryngeal carcinoma cell and its significance].

Abstract

OBJECTIVE:

To study the expression of perlecan in human laryngeal carcinoma cells and its significance.

METHOD:

The expression of perlecan mRNA in human laryngeal carcinoma cells, Hep-2 cells were investigated by using the techniques of semi-quantify RT-PCR. The expression of perlecan in the Hep-2 cells was investigated by using the techniques of immunohistochemistry.

RESULT:

It showed that the expression level of perlecan and perlecan mRNA significantly increased in Hep-2 cells as compared with the normal cells, Hacat cells (P < 0.01).

CONCLUSION:

These data raise the possibility that perlecan many play key roles in the growth,invasion and metastasis of human laryngeal carcinoma cells through either a paracrine or an autocrine mechanism.

• Authors: Guangli Chen, Juan Ding, Linghui Luo, Yingpeng Liu, Kaisheng Yan, Pei Chen, Peng Song, Yong Fu, Jianting Wang, Shusheng Gong
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 20 Issue 2 Pg. 78-80 (Jan 2006) China
• PMID: 16570819 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heparan Sulfate Proteoglycans
• RNA, Messenger
• perlecan

Topics

• Carcinoma, Squamous Cell (metabolism, pathology)
• Cell Line, Tumor
• Heparan Sulfate Proteoglycans (metabolism)
• Humans
• Laryngeal Neoplasms (metabolism, pathology)
• RNA, Messenger (genetics)