| Abstract | A 45-year-old Japanese male was diagnosed with adult onset Still's disease (AOSD). High-dose corticosteroid initially resolved the illness; however, high fever, maculopalpular rashes, arthralgia, and acute pericarditis rapidly recurred, and were followed by a somnolent state without focal signs. A diagnosis of corticosteroid resistant, severe, recurrent AOSD was made, and double-filtration plasmapheresis (DFPP) was performed immediately. The somnolent state began to resolve during the first plasmapheresis procedure, and the other symptoms resolved shortly thereafter. DFPP theoretically removes monocyte-activating cytokines, such as monocyte colony-stimulating factor (M-CSF) from the circulation, and therefore may prove to be an effective treatment for corticosteroid resistant, rapidly developing cases of AOSD. |
| Authors | Takashi Kato, Tatsuo Kobayashi, Hiroshi Nishino, Yuji Hidaka
(Affiliation: Department of Rheumatology, Kameda Medical Center, 929 Higashi-cho, Kamogawa City, Chiba, 296-8602, Japan. kintarou at s9.dion.ne.jp)
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| Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 25
Issue 4
Pg. 579-82
(Jul 2006)
ISSN: 0770-3198 Belgium |
| PMID | 16568213
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
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| Topics |
- Adrenal Cortex Hormones
(pharmacology)
- Filtration
- Humans
- Japan
- Male
- Middle Aged
- Plasmapheresis
(methods)
- Recurrence
- Remission Induction
- Still's Disease, Adult-Onset
(therapy)
- Tomography, X-Ray Computed
- Treatment Outcome
|
