Abstract |
Evaluation trials of the efficacy of buparvaquone (BUTA-kel KELA Laboratoria, N.V. Belgium), as a treatment of field cases of Theileria parva infection ( East Coast fever - ECF) were carried out on 63 cattle in the peri-urban of Dar Es Salaam city, Tanzania, during the period November 2004 to August 2005. Thirty-two cattle (56%) received single-dose treatment (2.5 mg buparvaquone per kg body weight), while two and three-dose treatment with interval(s) of 48 h was given to 33% and 11% of total treated cattle, respectively; 38 cattle (60.3%) were treated at an early stage of the disease, while 25 cattle (39.7%) were treated at an advanced stage of the disease. The rectal body temperature of 90.5% of buparvaquone-treated cattle dropped to normal values (37.5-39.5 degrees C) by day 7 of treatment, and by day 15 of treatment 96.8% of treated cattle showed normal values. Pulmonary signs were observed in 8/68 (11.8%) of total ECF diagnosed cattle and were successfully treated, albeit with parvaquone plus frusemide (Fruvexon); were not included in final evaluation of the efficacy of BUTA-kel. The present evaluation trials record a recovery rate of 95.2%. Buparvaquone (BUTA-kel KELA Laboratoria, N.V. Belgium), therefore, records another efficacious and valuable alternative treatment against East Coast fever in Tanzania.
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Authors | H A Mbwambo, H B Magwisha, J M Mfinanga |
Journal | Veterinary parasitology
(Vet Parasitol)
Vol. 139
Issue 1-3
Pg. 67-73
(Jun 30 2006)
ISSN: 0304-4017 [Print] Netherlands |
PMID | 16567050
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiprotozoal Agents
- Naphthoquinones
- buparvaquone
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Topics |
- Animals
- Antiprotozoal Agents
(pharmacology, therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy)
- Female
- Male
- Naphthoquinones
(pharmacology, therapeutic use)
- Tanzania
- Theileria parva
(drug effects)
- Theileriasis
(drug therapy)
- Treatment Outcome
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