Sutureless nephron-sparing surgery: use of albumin glutaraldehyde tissue adhesive (BioGlue).

To determine the feasibility of using serum albumin glutaraldehyde tissue adhesive (BioGlue) to achieve hemostasis and prevent urine leakage during nephron-sparing surgery (NSS).
From February 1993 to April 2005, 174 NSS operations were performed for renal cell carcinoma at our institute. A total of 143 patients underwent NSS with the traditional suturing technique (suture group) and 31 patients underwent a sutureless BioGlue sealing-only procedure (BioGlue group). We compared the two groups for clinical and tumor characteristics and surgical outcome.
The patient and tumor characteristics were similar in both groups. The average maximal tumor diameter was 4.21 cm (range 2.2 to 7) for the suture group and 3.67 cm (range 2 to 6.8) for the BioGlue group. The use of BioGlue reduced the mean warm ischemic time by 8.8 minutes (17.2 versus 26 minutes, P = 0.002). The mean estimated blood loss was 45.1 mL in the BioGlue group and 111.7 mL in the suture group (P = 0.001). Blood transfusion was required in 1 patient (3.2%) of the BioGlue group and 24 (17%) in the suture group (P = 0.014). None of the patients treated with BioGlue developed urinary fistula compared with three (2%) in the suture group.
Albumin glutaraldehyde tissue adhesive (BioGlue) alone provided adequate hemostasis during NSS, significantly decreasing the blood loss and transfusion rate, as well as the renal ischemic and operative times. BioGlue was easy to use and safe for sealing the kidney during partial nephrectomy. Future prospective clinical trials are necessary to validate its role during renal surgery.
AuthorsG Hidas, A Kastin, M Mullerad, J Shental, B Moskovitz, O Nativ
JournalUrology (Urology) Vol. 67 Issue 4 Pg. 697-700; discussion 700 (Apr 2006) ISSN: 1527-9995 [Electronic] United States
PMID16566976 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Bio-glue
  • Proteins
  • Tissue Adhesives
  • Adult
  • Aged
  • Carcinoma, Renal Cell (surgery)
  • Feasibility Studies
  • Female
  • Humans
  • Kidney Neoplasms (surgery)
  • Male
  • Middle Aged
  • Nephrectomy (methods)
  • Nephrons
  • Proteins
  • Suture Techniques
  • Tissue Adhesives

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