Enhancement and hepatocyte-modulating effect of chemical mediators and monokines produced by hepatic macrophages in rats with induced sepsis.

Abstract

We investigated the production of chemical mediators by hepatic macrophages from rats with sepsis and the modulation of hepatocyte function by these hepatic macrophages. The chemical mediators we measured were superoxide (O2-), TNF, IL-1, and PGE2. Production of these mediators by hepatic macrophages from rats with sepsis was significantly increased. Furthermore, protein synthesis by cultured hepatocytes was inhibited in a co-culture system of hepatocytes and hepatic macrophages from rats with sepsis, and it was even inhibited by the supernatant of cultured hepatic macrophages from septic rats. These results demonstrate that hepatic macrophages are activated in sepsis and may play a role in inducing hepatic dysfunction in sepsis.

• Authors: K Monden, S Arii, S Itai, T Sasaoki, Y Adachi, N Funaki, H Higashitsuji, T Tobe
• Journal: Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie (Res Exp Med (Berl)) Vol. 191 Issue 3 Pg. 177-87 ( 1991) ISSN: 0300-9130 [Print] Germany
• PMID: 1656500 (Publication Type: Journal Article)

Chemical References

• Interleukin-1
• Monokines
• Tumor Necrosis Factor-alpha
• Superoxides
• Dinoprostone

Topics

• Animals
• Dinoprostone (biosynthesis)
• Interleukin-1 (biosynthesis)
• Liver (immunology, metabolism)
• Macrophage Activation (physiology)
• Macrophages (immunology, metabolism)
• Male
• Monokines (biosynthesis)
• Protein Biosynthesis
• Rats
• Rats, Inbred Strains
• Superoxides (metabolism)
• Tumor Necrosis Factor-alpha (biosynthesis)