Abstract | AIM:
Adenocarcinoma of the prostate is one of the most frequently diagnosed non-cutaneous cancers and the second leading cause of cancer-related deaths among men in the United States. To fully understand the role of ceramide during apoptosis induced by androgen ablation, we modified the levels of intracellular ceramide by pharmacological agents as well as through serum deprivation in androgen-dependent and independent cell lines. METHODS: RESULTS: CONCLUSIONS: Our studies indicate that the increase in intracellular ceramide itself, but not the balance between ceramide and S1P, determines whether LNCaP cells undergo apoptosis. Our results also show that the increase in intracellular ceramide strongly correlates with apoptosis induced by serum deprivation even in androgen-independent prostate cancer cell lines.
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Authors | Masatoshi Eto, Jaafar Bennouna, Oriana C Hunter, Michael T Lotze, Andrew A Amoscato |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 13
Issue 2
Pg. 148-56
(Feb 2006)
ISSN: 0919-8172 [Print] Australia |
PMID | 16563140
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Androgen Antagonists
- Ceramides
- N-palmitoylsphingosine
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Androgen Antagonists
(pharmacology)
- Apoptosis
- Cell Line, Tumor
- Ceramides
(metabolism, physiology)
- Humans
- Male
- Prostatic Neoplasms
(metabolism, pathology)
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