The effects of drugs with hypolipidemic properties in the prevention of the atherothrombotic
vascular disease, go further than reducing serum
lipids, suggesting that there are other nonlipid-related mechanisms involved; the maintenance of appropriate haemostatic balance being one of them. The objective of this investigation was a
drug intervention with ciprofibrat in hyperlipidemic people with high level of plasmatic
fibrinogen with the purpose of knowing the effects of the
drug over these risk factors and other haemostatic parameters. Forty people, both sexes, 20 of them apparently healthy and the other 20 with clinical and angiographic evidence of
coronary artery disease, were randomized to receive 100 mg of ciprofibrat or placebo during an average of 56 weeks. All of them had a clinical exam, EKG and stress test. Laboratory exams included
lipid profile, plasma
fibrinogen (Fg), VII factor, vonWillebrand factor,
protein C (PC) and the
tissue plasminogen activator with samples taken every 8 weeks. The Ciprofibrat group showed significant changes of
lipids:
cholesterol -23%,
triglycerides -31%,
high-density lipoprotein (HDLc) +24% and
very low-density lipoprotein -23%, except
low-density lipoprotein -24%. The haemostatic parameters in 40 weeks showed that Fg decreased 21% (p = 0.001), decreasing to 9% at the end of the follow-up. In the placebo group the HDLc showed
a 10% increase (p = 0.02), PC reduced to 20% (p = 0.01) and Fg kept blood levels close to basal line, descending 10% at the end of the follow-up. In this study, the use of ciprofibrat in patients with high risk of developing atherothrombotic events, showed efficiency and security in handling
hyperlipidemia, such as keeping and appropriate haemostatic balance.