Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.

Abstract

AIM:

To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis.

MATERIAL AND METHODS:

Forty-three patients participated in this randomized clinical trial divided into four groups. Six weeks after scaling and root planning (SRP), groups 1-3 received adjunctive metronidazole, plus amoxicillin, doxycycline and metronidazole respectively, and group 4 acted as controls. Clinical recordings concerning probing depth, probing attachment level and bleeding on probing were performed at baseline, 6 weeks after SRP and 6 months from baseline. Subgingival samples were analysed using the 'checkerboard' DNA-DNA hybridization for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Tannerella forsythia and Treponema denticola.

RESULTS:

All treatments resulted in improvement of clinical parameters (ANOVA p > 0.05). Systemic administration of metronidazole plus amoxicillin or metronidazole resulted in statistically significant greater reduction of the proportion of sites > 6 mm than SRP (z-test, p < 0.05). These antimicrobials yielded a significant effect on levels of important periodontal pathogens for 6 months.

CONCLUSION:

Adjunctive metronidazole plus amoxicillin or metronidazole alone (when A.actinomycetemcomitans is not involved) is effective in deep pockets of aggressive periodontitis patients.

• Authors: Christiana Xajigeorgiou, Dimitra Sakellari, Theodora Slini, Anneta Baka, Antonis Konstantinidis
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 33 Issue 4 Pg. 254-64 (Apr 2006) ISSN: 0303-6979 [Print] United States
• PMID: 16553634 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Metronidazole
• Amoxicillin
• Doxycycline

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (drug effects, isolation & purification)
• Amoxicillin (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Anti-Infective Agents (therapeutic use)
• Bacteroides (drug effects, isolation & purification)
• Colony Count, Microbial
• Dental Scaling
• Doxycycline (therapeutic use)
• Female
• Follow-Up Studies
• Gingival Hemorrhage (drug therapy)
• Humans
• Male
• Metronidazole (therapeutic use)
• Middle Aged
• Periodontal Attachment Loss (drug therapy)
• Periodontal Pocket (drug therapy)
• Periodontitis (drug therapy, microbiology)
• Porphyromonas gingivalis (drug effects, isolation & purification)
• Root Planing
• Treponema denticola (drug effects, isolation & purification)