Abstract | CONTEXT: OBJECTIVE: Our objective was to investigate a functional polymorphism in HSD11B1 (T-->G in the third intron rs12086634, which associates with lower 11beta-HSD1 activity) in PCOS with and without obesity. DESIGN AND SETTING: We conducted a case-control study in lean and obese PCOS patients and controls at an academic hospital. PARTICIPANTS: Participants included 102 Caucasian PCOS patients and 98 controls comparable for age, weight, and race. MAIN OUTCOME MEASURES: We assessed genotype distribution and influence of genotypes on clinical, hormonal, and metabolic parameters. RESULTS: CONCLUSIONS:
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Authors | Alessandra Gambineri, Valentina Vicennati, Silvia Genghini, Federica Tomassoni, Uberto Pagotto, Renato Pasquali, Brian R Walker |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 91
Issue 6
Pg. 2295-302
(Jun 2006)
ISSN: 0021-972X [Print] United States |
PMID | 16551740
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Dehydroepiandrosterone Sulfate
- Adrenocorticotropic Hormone
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
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Topics |
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
(genetics)
- Adrenocorticotropic Hormone
(pharmacology)
- Adult
- Case-Control Studies
- Cholesterol, LDL
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Female
- Genetic Variation
- Genotype
- Humans
- Hyperandrogenism
(genetics)
- Polycystic Ovary Syndrome
(genetics)
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