Tc-99m depreotide imaging of I-131-negative recurrent metastatic papillary thyroid carcinoma.

Abstract

The detection of radioiodine (I-131)-negative metastases of differentiated thyroid carcinoma (DTC) has been hitherto successfully tried by the well-known synthetic somatostatin analogue indium-111-labeled DTPA-octreotide (In-111 pentetreotide). The objective of this study was to evaluate the usefulness of scintiscan with the newer synthetic somatostatin analogue Tc-99m depreotide, in the restaging of papillary thyroid carcinoma (PTC) with detectable serum thyroglobulin (Tg) levels and negative I-131 whole-body scan (WBS). Whole-body planar and cervico-thoracic tomographic scintigraphy (single-photon emission tomography-SPET) with Tc-99m depreotide was performed in a 68-year-old male patient suffering from PTC stage III, with a mild increase in serum Tg levels coupled with a recent negative I-131 WBS. The findings were compared with those of neck ultrasonography (US) and computerized tomography (CT). Nodal neck dissection and histopathology provided the definitive diagnosis. Tc-99m depreotide scanning revealed foci of cervical lymph node metastases, which did not accumulate I-131. The findings were in accordance with neck US and CT. Histopathology established the diagnosis of metastatic cervical lymph node PTC. Lymph node immunoreactivity was positive for the somatostatin receptor subtypes 2, 5 and 3. Scintigraphy with Tc-99m depreotide could prove a useful adjunct to the armamentarium for the follow-up of PTC, especially in the setting of detectable serum Tg and negative I-131 WBS.

• Authors: Pipitsa Valsamaki, Anna Gotzamani-Psarrakou, Spyridon Tsiouris, Elissavet Molyvda-Athanasopoulou, Kyriakos Psarrakos, Vassilios Papantoniou, Sophia Gerali, Cherry Zerva
• Journal: International journal of cancer (Int J Cancer) Vol. 119 Issue 4 Pg. 968-70 (Aug 15 2006) ISSN: 0020-7136 [Print] United States
• PMID: 16550594 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2006 Wiley-Liss, Inc.

Chemical References

• Iodine Radioisotopes
• Organotechnetium Compounds
• Somatostatin
• technetium Tc 99m depreotide

Topics

• Aged
• Carcinoma, Papillary, Follicular (diagnosis)
• Humans
• Iodine Radioisotopes
• Male
• Neoplasm Metastasis (diagnosis)
• Neoplasm Recurrence, Local (diagnosis)
• Organotechnetium Compounds
• Somatostatin (analogs & derivatives)
• Thyroid Neoplasms (diagnosis)