[Acute obstructive kidney failure during sulfadiazine treatment].

Abstract

INTRODUCTION:

Acute obstructive kidney failure can occur during sulfadiazine treatment of cerebral toxoplasmosis in immunocompromised patients.

CASE:

Six days after the patient began sulfadiazine treatment for toxoplasmosis, he developed low back pain radiating into the abdomen and kidney failure with obstructive uropathy, followed by anuria. Abdominal computed tomography found bilateral pyelocaliceal distention. Six hours after a hemodialysis session, the pain stopped abruptly and abundant diuresis resumed.

DISCUSSION:

During acute renal failure due to sulfadiazine, simply stopping the drug treatment does not suffice. The massive alkalinization induced by hemodialysis, however, is effective.

• Authors: Hervé Hyvernat, Philippe de Swardt, Véronique Mondain, Gilles Bernardin
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 35 Issue 3 Pt 1 Pg. 423-4 (Mar 2006) ISSN: 0755-4982 [Print] France
• Vernacular Title: Insuffisance rénale aiguë obstructive lors d'un traitement par sulfadiazine.
• PMID: 16550134 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Sulfadiazine

Topics

• Acute Disease
• Anti-Infective Agents (adverse effects, therapeutic use)
• Humans
• Male
• Middle Aged
• Renal Dialysis
• Renal Insufficiency (chemically induced)
• Sulfadiazine (adverse effects, therapeutic use)
• Toxoplasmosis (drug therapy)