Abstract |
To determine the role of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) in extranodal NK/T-cell lymphoma patients, we conducted a retrospective analysis. In our previous study, we searched for patients who had received HDC/ASCT and identified 16 eligible patients and compared the treatment outcome with historical control group (n=246). Nine patients received HDC/ASCT in the first (CR1) or second complete remission (CR2), while seven patients received HDC/ASCT as salvage. Twelve of 16 patients achieved or maintained CR after HDC/ASCT. Among the 12 patients, five patients relapsed. Estimated 2-year overall survival (OS) and relapse-free survival (RFS) rates were 71.3+/-12.4% and 25.8+/-14.3%, respectively. There was a tendency of better survival in patients who received HDC/ASCT as compared to those who did not (P=0.091). In subset analysis, patients who underwent HDC/ASCT at CR (P=0.049) and patients with stage III or IV (P=0.001) had a favorable outcome. Patients with NKIPI 3,4 or EUNKTL, who underwent HDC/ASCT had more prolonged survival without statistical significance (P=0.055 and 0.056). In conclusion, HDC/ASCT may be considered as a treatment option for patients with extranodal NK/T-cell lymphoma, especially those in CR, with advanced disease (stage III/IV or EUNKTL) and high NKIPI scores.
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Authors | H J Kim, S M Bang, J Lee, H C Kwon, C Suh, H J Kim, J H Lee, B Y Ryoo, Y H Park, J M Kwon, S Y Oh, H R Lee, K Kim, C W Jung, K Park, W S Kim |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 37
Issue 9
Pg. 819-24
(May 2006)
ISSN: 0268-3369 [Print] England |
PMID | 16547486
(Publication Type: Comparative Study, Journal Article)
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Copyright | Bone Marrow Transplantation (2006) 37, 819-824. doi:10.1038/sj.bmt.1705349; published online 20 March 2006. |
Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Combined Modality Therapy
- Female
- Humans
- Lymphoma, T-Cell
(mortality, therapy)
- Male
- Middle Aged
- Retrospective Studies
- Stem Cell Transplantation
(methods)
- Survival Analysis
- Survivors
- Time Factors
- Transplantation, Autologous
- Treatment Outcome
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