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High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases.

Abstract
To determine the role of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) in extranodal NK/T-cell lymphoma patients, we conducted a retrospective analysis. In our previous study, we searched for patients who had received HDC/ASCT and identified 16 eligible patients and compared the treatment outcome with historical control group (n=246). Nine patients received HDC/ASCT in the first (CR1) or second complete remission (CR2), while seven patients received HDC/ASCT as salvage. Twelve of 16 patients achieved or maintained CR after HDC/ASCT. Among the 12 patients, five patients relapsed. Estimated 2-year overall survival (OS) and relapse-free survival (RFS) rates were 71.3+/-12.4% and 25.8+/-14.3%, respectively. There was a tendency of better survival in patients who received HDC/ASCT as compared to those who did not (P=0.091). In subset analysis, patients who underwent HDC/ASCT at CR (P=0.049) and patients with stage III or IV (P=0.001) had a favorable outcome. Patients with NKIPI 3,4 or EUNKTL, who underwent HDC/ASCT had more prolonged survival without statistical significance (P=0.055 and 0.056). In conclusion, HDC/ASCT may be considered as a treatment option for patients with extranodal NK/T-cell lymphoma, especially those in CR, with advanced disease (stage III/IV or EUNKTL) and high NKIPI scores.
AuthorsH J Kim, S M Bang, J Lee, H C Kwon, C Suh, H J Kim, J H Lee, B Y Ryoo, Y H Park, J M Kwon, S Y Oh, H R Lee, K Kim, C W Jung, K Park, W S Kim
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 37 Issue 9 Pg. 819-24 (May 2006) ISSN: 0268-3369 [Print] England
PMID16547486 (Publication Type: Comparative Study, Journal Article)
CopyrightBone Marrow Transplantation (2006) 37, 819-824. doi:10.1038/sj.bmt.1705349; published online 20 March 2006.
Topics
  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Combined Modality Therapy
  • Female
  • Humans
  • Lymphoma, T-Cell (mortality, therapy)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Stem Cell Transplantation (methods)
  • Survival Analysis
  • Survivors
  • Time Factors
  • Transplantation, Autologous
  • Treatment Outcome

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