Abstract | BACKGROUND/AIMS: METHODS: We prospectively analyzed treatment and survival parameters of 148 cirrhotic patients with nonsurgical hepatocellular carcinoma who had undergone PLA at a single institution during an 11-year period. RESULTS: Single tumors were seen in 129 of 148 (87%) patients, and 2-3 nodules were seen in 19 (13%) patients, for a total of 169 tumors. The median overall time survival was 39 months (95% confidence interval [CI], 30-47 months). The 1-, 2-, 3-, 4-, and 5-year cumulative survival rates were 89, 75, 52, 43, and 27%, respectively. From multiple regression analysis, the independent predictors of survival were found to be tumor grading (P=0.002; risk ratio [RR] 0.37, 95% CI 0.20-0.70), bilirubin levels < or =2.5mg/dl (P=0.014; RR 1.58, 95% CI 1.09-2.28), and the achievement of complete tumor ablation (P=0.020; RR 0.53, 95% CI 0.31-0.90). An initial complete tumor ablation was the only factor associated with longer survival in patients with Child-Turcotte-Pugh class A cirrhosis (P=0.012; hazard ratio [HR] 0.48, 95% CI 0.23-1.03). CONCLUSIONS: A complete tumor ablation results in improved survival in all patients with nonsurgical hepatocellular carcinoma. Ideal candidates for PLA are those with a well-differentiated histology, and normal bilirubin levels.
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Authors | Claudio Maurizio Pacella, Giancarlo Bizzarri, Giampiero Francica, Giuseppe Forlini, Alessandra Petrolati, Dario Valle, Vincenzo Anelli, Antonio Bianchini, Stefano De Nuntis, Sara Pacella, Zaccaria Rossi, John Osborn, Roberto Stasi |
Journal | Journal of hepatology
(J Hepatol)
Vol. 44
Issue 5
Pg. 902-9
(May 2006)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 16545480
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Bilirubin
(blood)
- Carcinoma, Hepatocellular
(mortality, pathology, surgery)
- Female
- Follow-Up Studies
- Humans
- Laser Therapy
- Liver Neoplasms
(mortality, pathology, surgery)
- Male
- Middle Aged
- Necrosis
- Postoperative Complications
(mortality)
- Predictive Value of Tests
- Prospective Studies
- Regression Analysis
- Survival Analysis
- Treatment Outcome
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