Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI).

Abstract

To test whether MHC alleles associated with common variable immune deficiency (CVID) might also be over-represented in patients with normal serum immunoglobulin levels who suffer with recurrent sinopulmonary infections (RESPI), we identified 62 consecutive RESPI patients and compared their HLA-B and HLA-DR antigen frequencies to those of 60 consecutive patients with CVID, 1627 Alabama Caucasian bone marrow donors, and 997,230 published US Caucasians. Either HLA-B44, -B8, -DR3(17), or -DR7 was present in 74% of the RESPI and 85% of the CVID patients. HLA-B44 prevalence in particular proved identical between RESPI and CVID. When compared to US Caucasians, the increased prevalence of the four HLA alleles proved significant at P < 0.0001, P < 0.0001, P = 0.0005, and P = 0.02, respectively. When compared to Alabama Caucasians, only the increased prevalence of HLA-B44 achieved statistical significance (P = 0.0001). Inheritance of HLA-B44 may yield susceptibility to recurrent sinopulmonary infection even in the presence of normal serum immunoglobulin levels.

• Authors: Douglas T Johnston, Gregory Mehaffey, Judy Thomas, K Randall Young Jr, Howard Wiener, Jian Li, Rodney C P Go, Harry W Schroeder Jr
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 119 Issue 3 Pg. 346-50 (Jun 2006) ISSN: 1521-6616 [Print] United States
• PMID: 16542878 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• HLA-B Antigens
• HLA-B44 Antigen
• HLA-DR Antigens
• Immunoglobulins

Topics

• Adolescent
• Adult
• Common Variable Immunodeficiency (blood, genetics, immunology)
• Female
• Gene Frequency
• HLA-B Antigens (genetics, immunology)
• HLA-B44 Antigen
• HLA-DR Antigens (genetics, immunology)
• Haplotypes
• Humans
• Immunoglobulins (blood)
• Male
• Middle Aged
• Respiratory Tract Infections (blood, genetics, immunology)
• Sex Factors
• White People (genetics)