Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784].

The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.
In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma.
The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.
AuthorsBehzad Eftekhar, Mohammad Ghodsi, Azar Hadadi, Mousa Taghipoor, Samira Zabihyan Sigarchi, Vafa Rahimi-Movaghar, Ehsan Sherafat Kazemzadeh, Babak Esmaeeli, Farideh Nejat, Alireza Yalda, Ebrahim Ketabchi
JournalTrials (Trials) Vol. 7 Pg. 2 ( 2006) ISSN: 1745-6215 [Electronic] England
PMID16542035 (Publication Type: Journal Article)

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