Abstract | BACKGROUND: METHODS: Adult patients with magnetic resonance imaging (MRI) findings and/or clinical deterioration compatible with progressive LGO were eligible for the study if they were radiotherapy-naive. TMZ cycles were repeated every 28 days at a dose of 200 mg/m2 daily for 5 consecutive days. Clinical and MRI data were used to evaluate outcomes, and Kaplan-Meier estimates were used to assess the median time to tumor progression ( TTP). The 1p/19q status was analyzed from paired tumor-blood DNA samples using polymerase chain reaction-based microsatellite analysis. MGMT protein expression was estimated semiquantitatively by immunohistochemistry using paraffin embedded tumor sections. RESULTS: There were 28 patients who received treatment, and the median time from diagnosis to tumor progression was 33.5 months. The median number of TMZ cycles per patient was 12.5. Marked clinical improvements were recorded in 15 patients (54%), and objective responses were recorded in 17 patients (61%). The median TTP was 31 months, and the progression-free survival rate was 70% at 24 months. Loss of chromosome 1p and low MGMT protein expression were associated with objective response (P < .003 and P < .04, respectively). CONCLUSIONS: TMZ was active in patients with progressive LGO, and their response to treatment was associated with 1p deletion and low MGMT protein expression. The authors suggest the possible use of MGMT immunostaining as a surrogate marker for predicting tumor chemosensitivity.
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Authors | Netta Levin, Iris Lavon, Bracha Zelikovitsh, Dana Fuchs, Felix Bokstein, Yakov Fellig, Tali Siegal |
Journal | Cancer
(Cancer)
Vol. 106
Issue 8
Pg. 1759-65
(Apr 15 2006)
ISSN: 0008-543X [Print] United States |
PMID | 16541434
(Publication Type: Journal Article)
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Copyright | 2006 American Cancer Society |
Chemical References |
- Antineoplastic Agents, Alkylating
- Dacarbazine
- O(6)-Methylguanine-DNA Methyltransferase
- Temozolomide
|
Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Brain Neoplasms
(chemistry, drug therapy, genetics)
- Chromosomes, Human, Pair 1
(genetics)
- Chromosomes, Human, Pair 19
(genetics)
- DNA Repair
- Dacarbazine
(analogs & derivatives, therapeutic use)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Male
- Middle Aged
- O(6)-Methylguanine-DNA Methyltransferase
(analysis)
- Oligodendroglioma
(chemistry, drug therapy, genetics)
- Temozolomide
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