Zinc(II) and copper(II) complexes of beta-substituted hydroxylporphyrins as tumor photosensitizers.

Novel photosensitizers beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato zinc(II) (Zn(II)P) and beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato copper(II) (Cu(II)P) were synthesized and characterized. Their ability of producing singlet oxygen under irradiation was detected by the measurement of decomposition of 1,3-diphenylisobenzofuran (DPBF). The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. Results showed Zn(II)P having high anti-tumor activity, which presents a promising photosensitizer for photodynamic therapy.
AuthorsQimao Huang, Zhiquan Pan, Ping Wang, Zhangping Chen, Xiaolian Zhang, Hansheng Xu
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 11 Pg. 3030-3 (Jun 1 2006) ISSN: 0960-894X [Print] England
PMID16540316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Photosensitizing Agents
  • Porphyrins
  • Zinc Compounds
  • Copper
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Cell Proliferation (drug effects)
  • Copper (chemistry)
  • Humans
  • Hydroxylation
  • Molecular Structure
  • Photosensitizing Agents (chemical synthesis, chemistry, pharmacology)
  • Plasmids (genetics)
  • Porphyrins (chemical synthesis, chemistry, pharmacology)
  • Zinc Compounds (chemical synthesis, chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: