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Zinc(II) and copper(II) complexes of beta-substituted hydroxylporphyrins as tumor photosensitizers.

Abstract
Novel photosensitizers beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato zinc(II) (Zn(II)P) and beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato copper(II) (Cu(II)P) were synthesized and characterized. Their ability of producing singlet oxygen under irradiation was detected by the measurement of decomposition of 1,3-diphenylisobenzofuran (DPBF). The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. Results showed Zn(II)P having high anti-tumor activity, which presents a promising photosensitizer for photodynamic therapy.
AuthorsQimao Huang, Zhiquan Pan, Ping Wang, Zhangping Chen, Xiaolian Zhang, Hansheng Xu
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 11 Pg. 3030-3 (Jun 1 2006) ISSN: 0960-894X [Print] England
PMID16540316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Photosensitizing Agents
  • Porphyrins
  • Zinc Compounds
  • Copper
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Cell Proliferation (drug effects)
  • Copper (chemistry)
  • Humans
  • Hydroxylation
  • Molecular Structure
  • Photosensitizing Agents (chemical synthesis, chemistry, pharmacology)
  • Plasmids (genetics)
  • Porphyrins (chemical synthesis, chemistry, pharmacology)
  • Zinc Compounds (chemical synthesis, chemistry, pharmacology)

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