A blend of floating and pulsatile principles of drug delivery system would have the advantage that a
drug can be released in the upper GI tract after a definite time period of no drug release. A multiparticulate floating-pulsatile drug delivery system was developed using porous
calcium silicate (Florite RE) and
sodium alginate, for time and site specific drug release of
meloxicam.
Meloxicam was adsorbed on the Florite RE (FLR) by fast evaporation of
solvent from
drug solution containing dispersed FLR.
Drug adsorbed FLR
powder was used to prepare
calcium alginate beads by ionotropic gelation method, using 3(2) factorial design. Developed formulations were evaluated for yield, entrapment efficiency, image analysis, surface topography, mechanical strength, apparent density, buoyancy studies and dissolution studies. Entrapment efficiency of different formulations varied from 70% to 94%. Formulations show a lag period ranging from 1.9 to 7.8 h in acidic medium followed by rapid release of
meloxicam in simulated intestinal fluid USP, without
enzymes (SIF). Complete drug release in SIF occurred in less than 1h from the formulations. The size of beads varied from 2.0 to 2.7 mm for different batches. Prepared beads were spherical with crushing strength ranging from 182 to 1,073 g. Floating time was controlled by density of beads and hydrophobic character of
drug. A pulsatile release of
meloxicam was demonstrated by a simple drug delivery system which could be useful in chronopharmacotherapy of
rheumatoid arthritis.