Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats.

Abstract

Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.

• Authors: S Prabhu, Mallika Jainu, K E Sabitha, C S Shyamala Devi
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 44 Issue 3 Pg. 209-15 (Mar 2006) ISSN: 0019-5189 [Print] India
• PMID: 16538859 (Publication Type: Journal Article)

Chemical References

• Cardiotonic Agents
• Xanthones
• mangiferin
• Aspartate Aminotransferases
• Alanine Transaminase
• Isoproterenol

Topics

• Alanine Transaminase (metabolism)
• Animals
• Aspartate Aminotransferases (metabolism)
• Cardiotonic Agents (pharmacology)
• Dose-Response Relationship, Drug
• Isoproterenol (pharmacology)
• Male
• Myocardial Infarction (chemically induced, metabolism, pathology, prevention & control)
• Rats
• Rats, Wistar
• Xanthones (pharmacology)