Abstract | BACKGROUND: METHODS: A double-blind, randomized, placebo-controlled, cross-over trial was performed. Eight patients with primary dysmenorrhea and eight tuballigated, healthy subjects participated on days 1-2 of two consecutive menstruations. At each menstruation a bolus injection of 10 pmol/kg of vasopressin was administered before and during infusion of either 300 microg/min of atosiban or placebo. Intrauterine pressure was measured as area under the curve throughout the experiments. Ischemia markers in plasma and pain recorded by a visual analog scale were measured before and after each vasopressin injection as well as before and after the start of either atosiban or placebo infusion. RESULTS: CONCLUSIONS:
Atosiban reduces vasopressin-induced intrauterine pressure in both healthy volunteers and dysmenorrheics, and reported pain in subjects with dysmenorrhea. The ischemia markers are not a useful biomarker index in women with dysmenorrhea. The dysmenorrhea pain evoked by vasopressin correlated poorly with area under the curve, which may suggest that the effect is mediated by more than one V1a-like receptor. We conclude that this model with recordings in healthy women is useful in the evaluation of drug candidates for primary dysmenorrhea.
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Authors | Ragner Liedman, Lee Grant, Sarah Igidbashian, Ian James, Alison McLeod, Laurence Skillern, Mats Akerlund |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 85
Issue 2
Pg. 207-11
( 2006)
ISSN: 0001-6349 [Print] United States |
PMID | 16532916
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidiuretic Hormone Receptor Antagonists
- Biomarkers
- Hormone Antagonists
- Receptors, Vasopressin
- atosiban
- Vasopressins
- Vasotocin
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Topics |
- Adult
- Antidiuretic Hormone Receptor Antagonists
- Area Under Curve
- Biomarkers
(blood)
- Cross-Over Studies
- Double-Blind Method
- Dysmenorrhea
(drug therapy, physiopathology)
- Female
- Hormone Antagonists
(therapeutic use)
- Humans
- Ischemia
(blood)
- Pain Measurement
- Prospective Studies
- Receptors, Vasopressin
(metabolism, physiology)
- Treatment Outcome
- Uterine Contraction
(drug effects)
- Vasopressins
(physiology)
- Vasotocin
(analogs & derivatives, therapeutic use)
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