Sodium bis(hydroxyethyl)dithiocarbamate reduces acute lung tissue damage induced by cadmium in rats.

Abstract

The protective effect of three dithiocarbamates against lung tissue damage induced by a single intratracheal instillation of cadmium chloride was examined in rats. The relative efficacy of these compounds was tested by comparing characteristic features of lung tissue damage: the increase of lung weight, and the changes in the synthesis and content of structural proteins. Of three compounds administered intraperitoneally at a dose of 2.46 mmol/kg body weight, the most effective in suppressing lung damage was sodium bis(hydroxyethyl)dithiocarbamate (DEDTC). Its efficacy was dependent on the time interval between administration of cadmium chloride and the DEDTC. The parameters of lung tissue damage which were examined approached control values when DEDTC and cadmium chloride were administered simultaneously.

• Authors: V Kobrle, J Hurych, M Cikrt, M M Jones
• Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 16 Issue 4 Pg. 733-41 (May 1991) ISSN: 0272-0590 [Print] United States
• PMID: 1653160 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Piperidines
• Thiocarbamates
• Cadmium
• Sorbitol
• Copper
• 4-carboxamidopiperidine-N-dithiocarboxylate
• Ditiocarb
• dihydroxyethyldithiocarbamate
• Zinc
• N-benzylglucamine dithiocarbamate

Topics

• Animals
• Cadmium (antagonists & inhibitors, metabolism)
• Cadmium Poisoning (pathology, prevention & control)
• Connective Tissue (drug effects, metabolism)
• Copper (metabolism)
• Ditiocarb (therapeutic use)
• Lung (metabolism, pathology)
• Lung Diseases (chemically induced, pathology, prevention & control)
• Male
• Organ Size (drug effects)
• Piperidines (therapeutic use)
• Poisoning (drug therapy)
• Rats
• Rats, Inbred Strains
• Sorbitol (analogs & derivatives, therapeutic use)
• Thiocarbamates (therapeutic use)
• Zinc (metabolism)