Sentinel lymph node mapping with technetium-99m colloidal rhenium sulfide in patients with gastric carcinoma.

Abstract

BACKGROUND:

The objective of this study was to determine, with the use of technetium-99m colloidal rhenium sulfide, whether the concept of sentinel lymph nodes (SLNs) is applicable to gastric cancers.

METHODS:

Fifty-nine gastric cancer patients underwent radical gastrectomy and SLN mapping with an intraoperative hand-held gamma probe. After surgery, each transected lymph node was measured for radioisotope (RI) activities by a well-type scintillation counter.

RESULTS:

SLNs were detectable in 57 (96%) of 59 patients. The sensitivity, specificity, and diagnostic accuracy were calculated to be 83.3%, 100%, and 92.9%, respectively. Sensitivity was 100% in the T1 group, 91.6% in the T2 group, and 62.5% in the T3 group. When RI activities were measured with a well-type scintillation counter, every metastatic non-SLN was found to be situated in the same lymphatic basin as the SLNs.

CONCLUSION:

The SLN concept is applicable to patients with early gastric cancer (T1). SLN mapping is suitable for identifying the lymphatic basin in cases of gastric cancer.

• Authors: Erito Mochiki, Hiroyuki Kuwano, Youichi Kamiyama, Ryusuke Aihara, Toshihiro Nakabayashi, Hiroyuki Katoh, Takayuki Asao, Noboru Oriuchi, Keigo Endo
• Journal: American journal of surgery (Am J Surg) Vol. 191 Issue 4 Pg. 465-9 (Apr 2006) ISSN: 0002-9610 [Print] United States
• PMID: 16531137 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radiopharmaceuticals
• Technetium Compounds
• technetium Tc 99m rhenium colloid
• Rhenium

Topics

• Adenocarcinoma (diagnostic imaging, pathology, surgery)
• Adult
• Aged
• Female
• Humans
• Lymphatic Metastasis (diagnostic imaging)
• Male
• Middle Aged
• Prospective Studies
• Radionuclide Imaging
• Radiopharmaceuticals
• Rhenium
• Sentinel Lymph Node Biopsy
• Stomach Neoplasms (diagnostic imaging, pathology, surgery)
• Technetium Compounds