Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats.

Abstract

Two hundred twenty-six specific pathogenfree male and female F344 rats were exposed to nickel sulfide inhalations for 78 weeks (5 days/wk, 6 hr/day) and observed for an adiditional 30-week period. For the same amount of time, 214 rats were exposed to filtered room air and served as controls. Rats exposed to nickel sulfide showed a significantly higher incidence of pulmonary hyperplastic and neoplastic lesions originating from the bronchial and bronchiloo-alveloar segments. The overall incidence of lung tumors in the animals treated with nickel sulfide was 14 percent compared with 1 percent in the controls. Pulmonary inflammatory reactions were also greatly increased. Injection of an agent (hexachlorotetra-fluorobutane) that induced lung infarction did not increase the proportion of animals having lesions, nor did it alter the type of lesions found in animals exposed to nickel sulfide.

• Authors: A D Ottolenghi, J K Haseman, W W Payne, H L Falk, H N MacFarland
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 54 Issue 5 Pg. 1165-72 (May 1975) ISSN: 0027-8874 [Print] United States
• PMID: 165308 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Butanes
• Carcinogens
• Hydrocarbons, Fluorinated
• Nickel

Topics

• Animals
• Body Weight (drug effects)
• Butanes
• Carcinogens
• Environmental Exposure
• Female
• Germ-Free Life
• Humans
• Hydrocarbons, Fluorinated
• Hyperplasia (pathology)
• Infarction (chemically induced, complications)
• Lung Neoplasms (chemically induced, pathology)
• Male
• Neoplasms, Experimental (chemically induced, pathology)
• Nickel (toxicity)
• Pneumonia (chemically induced)
• Pulmonary Circulation
• Rats
• Retroviridae (isolation & purification)
• Time Factors