Abstract |
The aim of the study was to evaluate the Binax Now rapid immunochromatographic test (ICT) for the detection of Streptococcus pneumoniae urinary antigen in children suffering from potentially pneumococcal infections. A total of 287 patients, with a median age of 34.9 months and divided into 3 groups, were studied; the first group of patients with a suspected pneumococcal infection (n = 112), the second group with infectious symptoms nonsuggestive of a pneumococcal infection (n = 54), and the third group was composed of asymptomatic children (n = 121). In group 1, sensitivity of ICT was 100% and specificity was 55.9% (95% confidence interval, 44.1- 67.7). Forty-six (85.1%) patients from the second group were true negatives. Twenty-five (20.7%) patients from the third study group were nasopharyngeal pneumococcal carriers, and the ICT was positive in 13 carriers (10.7%). The high sensitivity level of ICT in our study indicates that a negative test could rule out a pneumococcal infection, contrasted with a poor specificity.
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Authors | Marie-Laure Charkaluk, Nicolas Kalach, Hector Mvogo, Eric Dehecq, Hélène Magentie, Josette Raymond, Dominique Gendrel, Odile Kremp, Anne Decoster |
Journal | Diagnostic microbiology and infectious disease
(Diagn Microbiol Infect Dis)
Vol. 55
Issue 2
Pg. 89-94
(Jun 2006)
ISSN: 0732-8893 [Print] United States |
PMID | 16530375
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Antigens, Bacterial
(urine)
- Carrier State
- Child
- Child, Preschool
- Female
- Humans
- Immunochemistry
(methods)
- Infant
- Male
- Nasopharynx
(microbiology)
- Otitis Media
(microbiology)
- Pneumococcal Infections
(diagnosis, urine)
- Pneumonia, Bacterial
(microbiology)
- Sensitivity and Specificity
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