Polyhedral boron compounds as potential diagnostic and therapeutic antitumor agents.

Abstract

The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.

• Authors: V I Bregadze, I B Sivaev, S A Glazun
• Journal: Anti-cancer agents in medicinal chemistry (Anticancer Agents Med Chem) Vol. 6 Issue 2 Pg. 75-109 (Mar 2006) ISSN: 1871-5206 [Print] Netherlands
• PMID: 16529534 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Boranes
• Boron Compounds

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Boranes (pharmacokinetics, therapeutic use)
• Boron Compounds (therapeutic use)
• Boron Neutron Capture Therapy (methods)
• Cell Line, Tumor
• Humans
• Neoplasms (diagnosis, drug therapy, radiotherapy)