[In vitro study of antiviral activity of Myramistin against measles and mumps viruses].

Abstract

The study was aimed at in vitro investigation of the Myramistin antiviral activity against the measles and mumps viruses in the Vero cell culture. The experiments with addition of myramistin simultaneously or at various periods after inoculation of the monolayer by the measles virus (Edmonson strain) or mumps virus (PetroNov/03 strain) revealed pronounced dose-dependent antiviral effect of the drug. It was shown that for prevention of replication of the measles and mumps viruses the optimal concentrations were 0.05 to 0.005%. The prospects of myramistin use as a prophylactic agent for infections caused by the measles and mumps viruses are discussed.

• Authors: A P Agafonov, G M Ignat'ev, V V Svistov, I V Smirnov, Iu S Krivoshein
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 50 Issue 5-6 Pg. 17-9 ( 2005) ISSN: 0235-2990 [Print] Russia (Federation)
• PMID: 16526604 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Benzalkonium Compounds
• miramistin

Topics

• Animals
• Antiviral Agents (pharmacology)
• Benzalkonium Compounds (pharmacology)
• Chlorocebus aethiops
• Dose-Response Relationship, Drug
• Measles virus (drug effects, physiology)
• Microbial Sensitivity Tests
• Mumps virus (drug effects, physiology)
• Vero Cells
• Virus Replication (drug effects)