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Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines.

Abstract
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
AuthorsHye Won Park, Sang-Un Choi, Nam-In Baek, Sung-Hoon Kim, Jae Soon Eun, Jae Heon Yang, Dae Keun Kim
JournalArchives of pharmacal research (Arch Pharm Res) Vol. 29 Issue 2 Pg. 131-4 (Feb 2006) ISSN: 0253-6269 [Print] Korea (South)
PMID16526276 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane
  • torilin
Topics
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • Apiaceae (chemistry)
  • Cell Line, Tumor
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fruit (chemistry)
  • Humans
  • Inhibitory Concentration 50
  • Sesquiterpenes (isolation & purification, pharmacology)
  • Sesquiterpenes, Guaiane (isolation & purification, pharmacology)

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