Abstract |
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
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Authors | Hye Won Park, Sang-Un Choi, Nam-In Baek, Sung-Hoon Kim, Jae Soon Eun, Jae Heon Yang, Dae Keun Kim |
Journal | Archives of pharmacal research
(Arch Pharm Res)
Vol. 29
Issue 2
Pg. 131-4
(Feb 2006)
ISSN: 0253-6269 [Print] Korea (South) |
PMID | 16526276
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Sesquiterpenes
- Sesquiterpenes, Guaiane
- torilin
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Topics |
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology)
- Apiaceae
(chemistry)
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Fruit
(chemistry)
- Humans
- Inhibitory Concentration 50
- Sesquiterpenes
(isolation & purification, pharmacology)
- Sesquiterpenes, Guaiane
(isolation & purification, pharmacology)
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