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A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.

Abstract
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes. The producing strain, BA13793, isolated from a soil sample collected in Seto, Aichi Prefecture, Japan, has a resemblance to Streptoverticillium mobaraense. The active principle was extracted from the mycelium of strain BA13793 with methanol and purified by Sephadex LH-20 column chromatography. BE-13793C showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
AuthorsK Kojiri, H Kondo, T Yoshinari, H Arakawa, S Nakajima, F Satoh, K Kawamura, A Okura, H Suda, M Okanishi
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 44 Issue 7 Pg. 723-8 (Jul 1991) ISSN: 0021-8820 [Print] England
PMID1652582 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Carbazoles
  • Indoles
  • Pyrroles
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors
  • BE 13793C
Topics
  • Animals
  • Antibiotics, Antineoplastic (chemistry, isolation & purification, therapeutic use)
  • Carbazoles
  • Carcinoma, Ehrlich Tumor (drug therapy)
  • Chemical Phenomena
  • Chemistry, Physical
  • Fermentation
  • Indoles (chemistry, isolation & purification, therapeutic use)
  • Leukemia L1210 (enzymology)
  • Leukemia P388 (drug therapy)
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Neoplasm Transplantation
  • Pyrroles (chemistry, isolation & purification, therapeutic use)
  • Streptomycetaceae (classification, metabolism)
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors
  • Tumor Cells, Cultured

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