Abstract |
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes. The producing strain, BA13793, isolated from a soil sample collected in Seto, Aichi Prefecture, Japan, has a resemblance to Streptoverticillium mobaraense. The active principle was extracted from the mycelium of strain BA13793 with methanol and purified by Sephadex LH-20 column chromatography. BE-13793C showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
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Authors | K Kojiri, H Kondo, T Yoshinari, H Arakawa, S Nakajima, F Satoh, K Kawamura, A Okura, H Suda, M Okanishi |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 44
Issue 7
Pg. 723-8
(Jul 1991)
ISSN: 0021-8820 [Print] England |
PMID | 1652582
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Carbazoles
- Indoles
- Pyrroles
- Topoisomerase I Inhibitors
- Topoisomerase II Inhibitors
- BE 13793C
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Topics |
- Animals
- Antibiotics, Antineoplastic
(chemistry, isolation & purification, therapeutic use)
- Carbazoles
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Chemical Phenomena
- Chemistry, Physical
- Fermentation
- Indoles
(chemistry, isolation & purification, therapeutic use)
- Leukemia L1210
(enzymology)
- Leukemia P388
(drug therapy)
- Magnetic Resonance Spectroscopy
- Mice
- Molecular Structure
- Neoplasm Transplantation
- Pyrroles
(chemistry, isolation & purification, therapeutic use)
- Streptomycetaceae
(classification, metabolism)
- Topoisomerase I Inhibitors
- Topoisomerase II Inhibitors
- Tumor Cells, Cultured
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