Photoallergic contact dermatitis from ketoprofen in southern Sweden.

Abstract

The non-steroidal anti-inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen-containing topical preparations usually includes severe eczematous reactions. Ketoprofen is derived from propionic acid, and it is also a substituted benzophenone and therefore structurally similar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our department with suspected photoallergic or allergic reactions after having used ketoprofen-containing gels. Photopatch testing with the photopatch standard series, the ketoprofen-containing gels and their ingredients, fenofibrate, benzophenone-3, benzophenone-10 and benzophenone-4, was performed. Photoallergic reactions to ketoprofen were noted in 35 patients and a simultaneous contact allergy to ketoprofen in 2 patients. Simultaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40% and 73% of the patients, respectively.

• Authors: Monika Hindsén, Erik Zimerson, Magnus Bruze
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 54 Issue 3 Pg. 150-7 (Mar 2006) ISSN: 0105-1873 [Print] England
• PMID: 16524438 (Publication Type: Journal Article)

Chemical References

• Allergens
• Anti-Inflammatory Agents, Non-Steroidal
• Gels
• Ketoprofen

Topics

• Adult
• Allergens (adverse effects, chemistry)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, chemistry)
• Dermatitis, Photoallergic (epidemiology, etiology, pathology)
• Female
• Gels (adverse effects, chemistry)
• Humans
• Ketoprofen (adverse effects, chemistry)
• Male
• Middle Aged
• Patch Tests
• Sweden (epidemiology)