Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects.

Abstract

There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44 % carbohydrate; 40 % fat; 16 % protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p < 0.001), representing 22 % total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.

• Authors: A M McKillop, J R Lindsay, S Au, K I Mahood, F P M O'Harte, P R Flatt, P M Bell
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 38 Issue 2 Pg. 94-7 (Feb 2006) ISSN: 0018-5043 [Print] Germany
• PMID: 16523409 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• C-Peptide
• Insulin

Topics

• Blood Glucose (analysis)
• C-Peptide (blood)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Food
• Homeostasis
• Humans
• Insulin (blood)
• Insulin-Secreting Cells (metabolism)
• Male
• Time Factors