Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: Comparing antibiotic versus placebo treated HIV-infected and uninfected women, there were few differences in mean gestational age at delivery, the percent of preterm births, the time between randomization and delivery, or BWT. Four weeks after the 24-week antibiotic/placebo course, bacterial vaginosis, and trichomoniasis were reduced by 49% to 61% in the antibiotic groups compared with the placebo groups. However, in both the HIV-infected and uninfected groups, the placentas showed no difference in the rate of histologic chorioamnionitis. There were significant differences between HIV-infected and uninfected women, with the former having less education, a history of more stillbirths, more STIs, and in this pregnancy, a lower BWT (2949 vs 3100 g, P < .0001). CONCLUSION:
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Authors | Robert L Goldenberg, Anthony Mwatha, Jennifer S Read, Samuel Adeniyi-Jones, Moses Sinkala, Gernard Msmanga, Francis Martinson, Irving Hoffman, Wafaie Fawzi, Megan Valentine, Lynda Emel, Elizabeth Brown, Victor Mudenda, Taha E Taha, Hptn024 Team |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 194
Issue 3
Pg. 650-61
(Mar 2006)
ISSN: 1097-6868 [Electronic] United States |
PMID | 16522393
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Chorioamnionitis
(prevention & control)
- Double-Blind Method
- Female
- HIV Infections
(prevention & control, transmission)
- Humans
- Infectious Disease Transmission, Vertical
(prevention & control)
- Pregnancy
- Premature Birth
(prevention & control)
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