[Toxic reduction and superior therapeutic effects on peritoneal carcinomatosis of etoposide particles suspended in oil in mice].

Abstract

Two dosage forms of etoposide diluted by saline solution (Etp-sol) and etoposide particles suspended in oil (Etp-oil) were examined for the toxicity and therapeutic effects when injected intraperitoneally (ip) in mice. The 50% lethal dose (LD50) values for two weeks observation were 135 mg/kg in Etp-oil and 108 mg/kg in Etp-sol. Two days after intraperitoneal transplantation of 10(6) cells/mouse of P388 leukemia to CDF1 male mice, etoposide was injected intraperitoneally in the form of Etp-oil or Etp-sol. In the mice receiving 20mg/kg of etoposide, 11 of 19 mice given Etp-oil and 3 of 20 given Etp-sol survived to day 60. In the mice receiving 80 mg/kg of etoposide, 1 in 20 treated with Etp-oil and 8 of 20 treated with Etp-sol died from by the toxicity.

• Authors: M Lee, T Takahashi, A Hagiwara, A Iwamoto, M Shimotuma, C Yoneyama, M Itoh, T Sasabe, C Sakakura, S Shobayashi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 18 Issue 11 Pg. 2033-7 (Aug 1991) ISSN: 0385-0684 [Print] Japan
• PMID: 1652233 (Publication Type: English Abstract, Journal Article)

Chemical References

• Delayed-Action Preparations
• Etoposide
• Iodized Oil

Topics

• Animals
• Body Weight (drug effects)
• Delayed-Action Preparations
• Etoposide (administration & dosage, therapeutic use, toxicity)
• Infusions, Parenteral
• Iodized Oil (administration & dosage)
• Lethal Dose 50
• Leukemia P388 (complications, pathology)
• Male
• Mice
• Mice, Inbred ICR
• Peritonitis (drug therapy, etiology, pathology)