Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients?

Abstract

Recent studies have reported an imbalance between n6 and n3 fatty acids (AA and DHA) in subjects with CF. Alterations in fatty acid amounts are present in CFTR-expressing tissues, plasma and in circulating blood cells. It has been reported that the correction of polyunsaturated fatty acid deficiency reversed the organ pathologies observed in CF knockout mice. We describe a CF child with an unusual clinical course presenting high molar percentage of DHA in plasma and red cells membrane during supplementation with 5-methyltetrahydrofolate and vitamin B12.

• Authors: Cinzia Scambi, Patrizia Guarini, Lucia De Franceschi, Lisa Maria Bambara
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 5 Issue 3 Pg. 197-9 (Aug 2006) ISSN: 1569-1993 [Print] Netherlands
• PMID: 16516563 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fatty Acids, Omega-6
• Tetrahydrofolates
• Docosahexaenoic Acids
• Folic Acid
• Chymotrypsin
• 5-methyltetrahydrofolate

Topics

• Adult
• Chymotrypsin (analysis)
• Cystic Fibrosis (drug therapy, metabolism)
• Dietary Supplements
• Docosahexaenoic Acids (blood, metabolism)
• Fatty Acids, Omega-6 (blood, metabolism)
• Female
• Folic Acid (pharmacology)
• Humans
• Infant, Newborn
• Methylation
• Milk, Human (chemistry)
• Tetrahydrofolates (pharmacology)