| Abstract | OBJECTIVE: Proliferative activity (PA) may be an indicator of a neoplasm's malignant potential, and it has been described as a prognostic factor in different malignant tumors. It was our aim to study the prognostic significance of PA defined by Ki-S5 and Ki-S2 immunohistochemical staining in a large homogeneously treated cohort with primary advanced-stage ovarian carcinomas. METHODS: Immunohistochemical detection of PA was performed using monoclonal Ki-S5 and Ki-S2 antibodies and standard immunostaining protocols. Kaplan-Meier survival analysis and Cox regression multivariate analysis were performed. RESULTS: High Ki-S5 PA was associated with a better prognosis. This finding was statistically significant after univariate and multivariate analysis. A similar trend was found in the subgroup of completely debulked patients. No prognostic effect of Ki-S2 PA could be detected in the present study. CONCLUSION: High Ki-S5 PA is an indicator of a more favourable prognosis in patients with advanced ovarian carcinomas. Antiproliferative chemotherapy may be more effective in tumors which are highly proliferative, possibly due to an increased chemosensitivity. |
| Authors | Stefan Kommoss, Andreas du Bois, Dietmar Schmidt, R Parwaresch, Jacobus Pfisterer, Friedrich Kommoss
(Affiliation: Institute of Pathology, 68159 Mannheim, Germany. stefan.kommoss at gyn-patho.de)
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| Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 103
Issue 1
Pg. 67-71
(Oct 2006)
ISSN: 0090-8258 United States |
| PMID | 16516280
(Publication Type: Journal Article)
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| Chemical References |
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| Topics |
- Aged
- Antibodies, Monoclonal
(chemistry)
- Cell Growth Processes
(physiology)
- Clinical Trials, Phase II as Topic
- Cohort Studies
- Combined Modality Therapy
- Female
- Humans
- Immunohistochemistry
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(drug therapy, pathology, surgery)
- Paraffin Embedding
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Randomized Controlled Trials as Topic
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