Chemotherapy may be more effective in highly proliferative ovarian carcinomas--a translational research subprotocol of a prospective randomized phase III study (AGO-OVAR 3 protocol).
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| Abstract | OBJECTIVE: Proliferative activity (PA) may be an indicator of a neoplasm's malignant potential, and it has been described as a prognostic factor in different malignant tumors. It was our aim to study the prognostic significance of PA defined by Ki-S5 and Ki-S2 immunohistochemical staining in a large homogeneously treated cohort with primary advanced-stage ovarian carcinomas. METHODS: Immunohistochemical detection of PA was performed using monoclonal Ki-S5 and Ki-S2 antibodies and standard immunostaining protocols. Kaplan-Meier survival analysis and Cox regression multivariate analysis were performed. RESULTS: High Ki-S5 PA was associated with a better prognosis. This finding was statistically significant after univariate and multivariate analysis. A similar trend was found in the subgroup of completely debulked patients. No prognostic effect of Ki-S2 PA could be detected in the present study. CONCLUSION: High Ki-S5 PA is an indicator of a more favourable prognosis in patients with advanced ovarian carcinomas. Antiproliferative chemotherapy may be more effective in tumors which are highly proliferative, possibly due to an increased chemosensitivity.
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| Authors | Stefan Kommoss, Andreas du Bois, Dietmar Schmidt, R Parwaresch, Jacobus Pfisterer, Friedrich Kommoss |
| Journal | Gynecologic oncology (Gynecol Oncol) Vol. 103 Issue 1 Pg. 67-71 (Oct 2006) ISSN: 0090-8258 [Print] United States |
| PMID | 16516280 (Publication Type: Journal Article) |
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